Madisonburg is an unincorporated community and census-designated place in Miles Township, Centre County, Pennsylvania, United States. It is part of the State College, Pennsylvania Metropolitan Statistical Area. The population was 168 at the 2010 census.Madisonburg is located in eastern Centre County at 40°55′37″N 77°31′2″W / 40.92694°N 77.51722°W / 40.92694; -77.51722, in the western part of Miles Township. It is in the Brush Valley, part of the Ridge-and-Valley Province of the Appalachian Mountains. The valley lies between the parallel ridges of Nittany Mountain to the north and Brush Mountain to the south.Pennsylvania Route 445 is the main street of the town, leading north across Nittany Mountain 7 miles to Pennsylvania Route 64 in Nittany, which itself is 3 miles southwest of Interstate 80.